A powerful, unique yeast probiotic
Saccharomyces boulardii is a nonpathogenic, transient yeast long used to support normal bowel transit time.†
It is a hardy, acid-resistant, temperature tolerant microorganism that is not affected by antibacterial agents. S. boulardii is genetically and functionally distinct from brewer’s yeast (S. cerevisiae) and different from pathogenic Candida species.
S. boulardii increases the activities of intestinal brush border enzymes such as disaccharidases, α-glucosidases, alkaline phosphatases, and aminopeptidases.†
S. boulardii augments the intestinal absorption of D-glucose coupled with sodium that may enhance uptake of water and electrolytes during occasional diarrhea.†
It increases stool concentrations of short-chain fatty acids that nourish colon mucosal cells.† S. boulardii modulates immunity by boosting intestinal secretion of IgA and increasing crypt cell immunoglobulin receptors.†
It supports healthy inflammatory response.† Research has found that S. boulardii supports healthy intestinal function in an array of clinical settings, supporting healthy bowel transit time.
ReThinkNutrients S. Boulardii is American Type Culture Collection (ATCC) certified and freeze-dried to maintain maximum strength and viability. ReThinkNutrients uses only lactose-free, gluten-free material. This hypoallergenic formula is available in vegetarian capsules.
60 VEGETARIAN CAPSULES
1 capsule twice daily with meals or as directed by a healthcare professional.
Free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. Contains no artificial colors, flavors, or preservatives.
If you are pregnant, nursing, have a medical condition, or taking prescription drugs, consult your healthcare professional before using this product. Keep out of reach of children.
The decision to utilize natural products should come only after thorough research. Some herbals, vitamins and minerals can actually interfere/negate the effects of pharmaceuticals and over-the-counter medications, while others may actually work in synergy to enhance their effects.
We recommend obtaining information through a variety of sources that utilize unbiased, science-based research studies: PubMed, Examine.com, AromaWeb and NAHA. You can use these resources and others to search for information on usage, safety and effectiveness.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. It is not intended as medical advice and it does not include all possible precautions, side effects, or interactions that may occur. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website.
Frequently Asked Questions
What is S. boulardii?
S. boulardii is a unique, non-pathogenic yeast that has been extensively researched and shown to support gastrointestinal health when taken as a dietary supplement.† ReThinkNutrients uses only certified S. boulardii to ensure maximum potency, efficacy, and safety. The S. Boulardii capsules should be taken with beverages or meals. If a person cannot swallow the capsules, they may be opened and the contents mixed with semi-solid foods such as applesauce or beverages. Avoid the use of hot foods or beverages as this may adversely affect the potency and activity of the supplement.
Does S. boulardii colonize the intestinal tract?
S. boulardii does not colonize the human intestinal tract and is not one of the microorganisms that normally inhabit the intestines. It is a transient yeast that passes through the intestines after ingestion. S. boulardii does not attach to the mucosal cells lining the intestines, but exerts its beneficial effects on the host as it moves through the gastrointestinal tract.
Is Saccharomyces boulardii the same as Saccharomyces cervisiae?
No, S. boulardii is not S. cerevisiae. S. boulardii is a wild, tropical yeast while S. cerevisiae is commonly known as brewer’s or baker’s yeast. Closely related to S. cerevisiae, S. boulardii is officially classified as Saccharomyces cerevisiae var boulardii Hansen CBS 5926. The 2 species have different genetic makeup and enzyme profiles. Unlike S. cerevisiae, S. boulardii does not make a certain type of reproductive spore called an ascospore and does not use the sugar galactose. It is very resistant to heat and acid and secretes a number of unique physiologically active factors. Only S. boulardii has proven gastrointestinal supportive effects.
Is S. boulardii the same as the yeast that causes yeast infections or overgrowth?
No, S. boulardii is completely unrelated to Candida albicans, C. tropicalas, C. krusie, and other Candida species that cause disease and overgrowth in the gastrointestinal and genitourinary tracts. Candida species decrease the acidity of the gastrointestinal mucosal environment, ultimately making the intestinal mucosal membrane susceptible to invasion by potentially harmful bacteria and yeast.
S. boulardii exerts the opposite effect producing lactic and other acids known to inhibit undesirable yeast species. S. boulardii is non-pathogenic (non-disease-causing) and has been shown in numerous clinical trials to be safe and effective.
What are the primary uses for S. boulardii?
S. boulardii has been used to positively affect gastrointestinal function in the following situations:
support the normal gastrointestinal microbiota during antibiotic use†
assist individuals with occasional diarrhea†
favorably modulate the normal gastrointestinal microbiota†
assist the body’s natural gastrointestinal detoxification process†
support host immune defenses and gut barrier function
How does S. boulardii work?
S. boulardii benefits the gastrointestinal tract in a variety of ways. It produces substances that create an environment that favorably shift the balance of gut microbiota towards more beneficial species.† It reduces the ability of undesirable bacteria and yeast to adhere to intestinal cells, thus helping keep these organisms under control.† S. boulardii augments gastrointestinal immune responsiveness, stimulates intestinal enzymes that enhance nutrient digestion and absorption, assists in mineral absorption, and helps nourish the colon.
How much S. boulardii should I take?
Daily doses ranging from 250 to 1,000 mg taken 1 to 4 times per day have been reported in the medical literature. There is no one standard supplement regimen for S. boulardii. It is prudent to consult a knowledgeable healthcare professional for advice on how much S. boulardii to take and for how long.
How long should I supplement with S. boulardii?
S. boulardii is generally used for short-term gastrointestinal support. Often the S. boulardii has been used for up to 2 weeks after a bout of occasional diarrhea has resolved. A common supplement regimen lasts 3 to 4 weeks.
How should ReThinkNutrients S. Boulardii be taken?
The Saccharomyces Boulardii capsules should be taken with beverages or meals. If a person cannot swallow the capsules, they may be opened and the contents mixed with semi-solid foods such as applesauce or beverages. Avoid the use of hot foods or beverages as this may adversely affect the potency and activity of the supplement.
Can S. boulardii be taken along with other probiotics?
Laboratory and clinical testing have demonstrated S. boulardii to be compatible with various lactic acid bacteria including the lactobacilli and bifidobacteria frequently used as probiotic supplements. Clinical studies suggest S. boulardii may work synergistically with other probiotics.
Can S. boulardii be taken along with antibiotics?
S. boulardii is naturally resistant to all antibacterial antibiotics and can be taken along with antibacterial antibiotics without adversely affecting its potency and efficacy. In fact, several clinical trials have used S. boulardii in conjunction with standard antibiotics and have demonstrated that S. boulardii enhances the success of antibiotic regimen. Additional studies have shown that S. boulardii can be taken along with antibiotics to support the gastrointestinal microbiota.†
Can S. boulardii be taken along with antifungals?
S. boulardii can be sensitive to a number of commonly prescribed antifungals including nystatin, Diflucan (fluconazol), and Sporonox (itraconazole) and these antifungal agents are known to kill the S. boulardii organisms. If antifungals are prescribed with S. boulardii then both products should be taken at different times. S. boulardii should be taken at least 1 hour before and 2 hours after any antifungal agent.
Can S. boulardii be taken along with natural or herbal antifungals?
There is debate within the healthcare community on this issue. However, there are no studies that show natural antifungal therapies such as garlic, grape seed extract, Oregon grape, or berberine affect the potency or actions of S. boulardii. It presently appears that S. boulardii can be taken along with natural antifungals.
Can S. boulardii be taken with prescription medications or other dietary supplements?
There is no known interaction between S. boulardii and prescription medicines except for antifungals. S. boulardii has no adverse interaction with other dietary supplements and can be added to any supplement regimen as needed.
Are there any conditions in which S. boulardii should not be taken?
S. boulardii is generally well tolerated however few contraindications exist. People with known allergies to Saccharomyces cervisiae should avoid use of S. boulardii. Currently no clinical studies on the safety of S. boulardii during pregnancy are available. Pregnant women should consult a healthcare professional before use. There have been reports of opportunistic infections in severely immunocompromised patients and in patients with indwelling vascular catheters after supplementation with S. boulardii. In rare cases, people with an indwelling vascular catheter sharing a hospital room with a person taking S. boulardii have developed catheter and blood stream S. boulardii infections. It is likely these catheter and blood infections were related to careless handling of the S. boulardii and poor handwashing by medical staff. S. boulardiishould be used with caution in severely immunocompromised patients. People with chronic indwelling vascular catheters should not use S. boulardii.
Is S. boulardii safe to use in infants and children?
S. boulardii has been shown to be safe in infants and children. In a clinical trial intended to evaluate the efficacy and safety of S. boulardii in infants and children, 250 mg was administered orally twice daily in 269 children aged 6 months to 14 years. No adverse effects were observed during the course of the study.
What improvements can be expected with supplementation?
Generally, clinical response is considered positive when the number of stools decrease and improvements in stool consistency, from being watery and foul-smelling to more formed and less odorous, are observed. Also lessening of occasional abdominal discomfort or cramping, along with reduction in stool urgency, and restoration of normal bowel movements provides clinical evidence of improvement.†
How long will it take for S. boulardii to clear from the gastrointestinal tract after discontuing use?
Clinical studies have demonstrated S. boulardii is usually eliminated from the healthy gastrointestinal tract within 6 days after discontinuation of supplementation. Occasionally S. boulardii may be cultured from the stool up to 4 weeks after discontinuing the supplement.
How should Saccharomyces boulardii be stored?
Store in a cool, dry place (59ºF to 85ºF) away from direct light. Keep out of reach of children.
Is ReThinkNutrients S. Boulardii a hypoallergenic product?
Yes. ReThinkNutrients S. Boulardii is free of lactose, casein, gluten, soy, egg, sugar, and maltodextrin. It is safe for use in children and adults following a gluten-free or casein-free diet. ReThinkNutrients S. Boulardii contains no artificial additives, colorings, flavoring, or preservatives.
Serving Size 1 Capsule
Amount Per Capsule % Daily Value
Probiotic Blend in a base of cellulose 320 mg *
Saccharomyces boulardii 3 billion CFU *
* Daily value not established
Vegetarian capsule (hydroxypropyl methylcellulose, water) and L-leucine.
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