Pig studies show that supplementing with oregano oil can be a promising approach for protecting the intestinal barrier by reducing intestinal inflammation harmful bacteria, and inflammatory cytokines, while strengthening the gut barrier. These collective actions help prevent endotoxin leakage into the bloodstream.

Studies support oregano's antibacterial properties, including against antibiotic resistant microbial strains such as: Tuberculosis (TB), Streptococcus (Strep), Staphylococcus (Staph), Escherichia coli (E. coli) and Salmonella.

• Substantial improvements were shown in the digestive capabilities and overall gut health of chickens fed Origanum minutiflorum.
• The digestive enzyme activities, in both the pancreas and small intestine, significantly increased in chickens fed Origanum minutiflorum.
• It was shown that Origanum minutiflorum essential oil may provide a progressive effect on the "quality of the intestines, secretion of digestive enzymes, and particularly the antioxidant defense potential against parasitic infections."
• Higher, longer and wider villi, as well as decreased crypt depth were observed in the duodenum, jejunum, and ileum areas of the intestines, "providing a greater surface area for nutrient digestion and absorption."
• These improvements contributed to "increased mucosal enzymes, absorption, and the efficiency of the nutrient transport system."
• Origanum minutiflorum helped to establish "microbial balance throughout the intestines, enhanced nutrient utilization and gut passage rates (motility), as well as encouraged endogenous digestive enzymatic activity", resulting in an overall "increased intestinal absorptive surface area."1)

Synergy exists in 100% pure, unadulterated oregano and other essential oils. However, many oregano essential oils are standardized to increase carvacrol, which affects the overall synergistic profile of the oil.